Efficacy against depressive symptoms. Regulatory approval of quetiapine monotherapy for bipolar depression was primarily based on two similar randomized controlled trials (RCTs) known by the acronyms BOLDER (BipOLar DEpRession) I and II. Seroquel Dosage for Bipolar Disorder The dose of Seroquel for bipolar disorder varies, depending on the particular type of bipolar disorder. The recommended starting dose of Seroquel for bipolar depression (in adults only) is Seroquel 50 mg, taken once daily at bedtime. Seroquel was already approved to treat the manic phases of bipolar disorder (formerly called manic-depressive illness). It had also been approved for the treatment of schizophrenia. Quetiapine immediate release (IR) was approved in 2006 for the treatment of depressive episodes in patients diagnosed with bipolar disorder. In 2008, the extended release formulation – quetiapine ER (Seroquel XR) – was also approved for the same indication. Seroquel in the Treatment of Dysphoric Hypomania in Bipolar II The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Bipolar disorder. Bipolar disorder is a lifelong condition that can affect both how you feel and how you act. It is a mood disorder thought to be caused by chemical imbalances in the brain that can result in extreme swings in mood—from manic highs to depressive lows. Detailed dosage guidelines and administration information for Seroquel (quetiapine fumarate). Includes dose adjustments, warnings and precautions. I am 28 years old and was Diagnosed with Bipolar II about a year and a half ago. I was on Effexor XR for a few years, for what I thought, and was told by my prior Psych was Depression (apparently not), along with either Xannax or Ativan for Panic Disorder which I also have. Detailed Quetiapine dosage information for adults, the elderly and children. Includes dosages for Depression, Bipolar Disorder and Depression; plus renal, liver and dialysis adjustments.